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黃瑞齡副教授頁面插圖

經歷

1.國立中國醫藥研究所副研究員

2.法國肝炎研究中心,客座進修

 

 

專長

l           中草藥抗B型肝炎病毒藥物之開發及分子生物層次之探討。

l           中草藥抗癌作用及機轉之探討。

 

 

重要研究計畫

l           執行之產學合作及教師專題研究計畫:

1.GK001萃取物抗B型肝炎病毒野生型及lamivudine抗藥性突變株作用之探討.葡萄王生技股份有限公司. 94-01-01 ~94-12-31

2.五種藥用蕈類萃取物抗B型肝炎病毒野生型及lamivudine 抗藥性突變株作用之探討.葡萄王生技股份有限公司. 94-01-01~94-12-31

3.中草藥抗B型肝炎病毒作用之研究. 葡萄王生物科技股份有限公司. 95-01-01~95-12-31

4.保健食品抗B型肝炎病毒之作用. 得榮生物科技股份有限公司. 95-01-01~95-12-31

5.中草藥抗流感病毒H1N1測定平台之建立教師專題研究計畫 95-01-01 ~95-12-31

6.藥用蕈類抗B型肝炎病毒之研究. 葡萄王生物科技股份有限公司. 96-01-01 ~96-12-31

7.Perillyl Alcohol抑制人類C型肝炎病毒作用之研究教師專題研究計畫 96-01-01

~96-12-31

8.藥用靈芝抗B型肝炎病毒之研究. 葡萄王生物科技股份有限公司. 97-01-01 ~97-12-31

9.歐前胡素抗B型肝炎病毒作用之探討教師專題研究計畫 97-01-01 ~97-12-31

10.葡萄王保健產品抗B型肝炎病毒作用之研究. 葡萄王生物科技股份有限公司. 98-01-01 ~98-12-31

11.麗豐保健產品抗B型肝炎病毒作用之研究. 麗豐實業股份有限公司. 98-01-01 ~98-12-31

12.琥珀中古生物DNA之探討教師專題研究計畫.98-01-01 ~98-12-31

13.穿心蓮抗腫瘤作用之探討教師專題研究計畫.98-01-01~98-12-31

14.萬寶祿特級本草活性酵素抑制B型肝炎病毒活性的評估. 教育部 &萬寶祿生技公司[教育部產業園區產學合作案].98-01-22~98-12-31

15.葡萄王保健蕈類產品抗B型肝炎病毒作用之研究. 葡萄王生物科技股份有限公司. 99-02-01 ~ 99-12-31

16.綠豆發酵產品抗B型肝炎病毒及免疫調控作用之研究. 京冠營養科技股份有限公司. 99-02-01 ~ 99-12-31

17.到手香萃取物抗B型肝炎病毒活性探討教師專題研究計畫.99-01-01 ~99-12-31

18.艾草萃取物抗B型肝炎病毒活性試驗教師專題研究計畫.99-01-01 ~99-12-31

19.樟芝發酵產品抗B型肝炎病毒活性檢測及有效成分之分離鑑定. 教育部&麗豐實業股份有限公司[教育部產業園區產學合作案]. 99-01-25~99-12-31

20.微生物發酵產品抗人類B型肝炎病毒檢測平台開發.99年度學界協助中小企業科技關懷計畫. 99-07-01~99-12-31

21.麗豐樟芝發酵產品降血糖活性分析. 教育部&麗豐實業股份有限公司[教育部產業園區產學合作案]. 100-02-09~100-12-31

22.中草藥抑制B型肝炎病毒作用之研究. 葡萄王生物科技股份有限公司. 100-06-01 ~ 101-05-31

23.益陞康牛樟芝抗B型肝炎病毒活性檢測及有效成分之分離鑑定. 教育部&億陞智生技有限公司[教育部產業園區產學合作案]. 101-01-18~101-12-31

l           執行國科會之研究計畫:

1.小本紅骨蛇木質酚素cB型肝炎病毒作用之探討 (NSC 89-2320-B-077-008- )

2.建立B型肝炎病毒抗lamivudine突變株的穩定轉殖細胞株及中草藥抗病毒突變株作用之探討(NSC 90-2320-B-077-004- )

3.牛樟芝抗B型肝炎病毒野生型和lamivudine抗藥性突變株活性成分之分離及作用機制之探討(NSC 91-2320-B-077-021- )

4.小蘗鹼抗人類B型肝炎病毒野生型及lamivudine抗藥性突變株作用及機制之探討(NSC 92-2320-B-077-011- )

5.抗病毒複方抑制人類B型肝炎病毒野生型及lamivudine抗藥性突變株作用及機制之探討(NSC 93-2320-B-276-001- )

6.EmodinB型肝炎病毒野生型及lamivudine抗藥性突變株作用及機制之探討 (NSC 94-2320-B-276-001-)

7.紫蘇醇抗B型肝炎病毒野生型及lamivudine抗藥性突變株作用及機制之探討 (NSC 95-2320-B-276-001-)

 

 

重要發表文獻

(A) 期刊論文

1.Huang, R.L., C.C. Chen, M.T. Hsieh, C.F. Chen, C.G. Chang, and Y.S.Chang. 1999. Screening on the Anti- hepatitis B Virus of Chinese Medicine Drugs. Journal of Chinese Medicine 10(4): 261-268.

2.Kuo, Y.H., S.Y. Li, M.D. Wu, R.L. Huang, L.M.Y. Kuo,  and C.F. Chen.1999. A New Anti-HBeAg Lignan, Kadsumarin A, from Kadsura matsudai and Schizandra arisanensis. Chemical & Pharmaceutical Bulletin 47(7):1047-1048. (SCI)

3.Lin, Y.L., R.L. Huang, Y.H. Kuo and C.F. Chen. 1999. Thiophenes from Echinops grijsii Hance. The Chinese Pharmaceutical Journal 51: 201-211.

4.Huang, R.L., C.C. Chen, Y.S. Chang, C.G. Chang, C.F. Chen, and M.T.Hsieh. 2000. Anti-Human Hepatitis B Virus Activities of Chinese Medicinal Prescriptions for the Treating of Liver Disease. Journal of Chinese Medicine 11(1): 1-8.

5.Huang, R.L., C.C. Chen, H.L.Huang, C.G. Chang, C.F. Chen,C.M.Chang,and M.T. Hsieh. 2000. Anti-Hepatitis  B Virus Effects of Wogonin Isolated from Scutellaria baicalensis Georgi. Planta Medica 66(8):694-698. (SCI)

6.Lin, Y.L., R.L. Huang, M.J. Don, and Y.H. Kuo. 2000. Dihydrophenanthrenes from Spiranthes sinenesis.  Journal of Natural Products 63: 1608-1610. (SCI)

7.Li S.Y., M.D. Wu, C.W. Wang, Y.H. Kuo, R.L. Huang,  and K.H. Lee.2000. A Novel Anti-HBeAg Homolignan,  Taiwanschirin D from Kadsura matsudai. Chemical & Pharmaceutical Bulletin 48(12): 1992-1993. (SCI)

8.Shen, C.C., R.L. Huang, H.F. Lin, J.F. Liao, and C.C. Chen. 2000. Synthesis and Cytotoxic Activity of Dicentrine Analogues. The Chinese Pharmaceutical Journal 52: 353-360.

9.Kuo, Y.H., S.Y. Li, R.L. Huang, M.D. Wu, H.C. Huang, and K.H. Lee.2001. Schizarin B, C, D, and E, Four New Lignans from Kadsura matsudai and Their Antihepatitis Activities. Journal of Natural Products 64,487-490.(SCI)

10.Huang, R.L., W.Y. Wang, Y.H. Kuo, and Y.L. Lin. 2001.Cytotoxic Triterpenes from the Fruit of Ziziphus jujuba. The Chinese Pharmaceutical Journal 53: 179-184.

11.Huang. Y.L., C.C. Chen, Y.J.Chen,R.L. Huang, and B.J. Shieh. 2001. Three Xanthones and a Benzophenone from Garcinia mangostana. Journalof Natural Products 64,903-906.(SCI)

12.Huang, R.L., C.F. Chen, H.Y. Feng, L.C. Lin, and C.J. Chou. 2001.Anti- Hepatitis B Virus of Seven Compounds Isolated from Piper kadsura (Choisy) Ohwi. Journal of Chinese Medicine 12(3): 179-190.

13.Lee I-Hung, R.L. Huang, C.T. Chen, H.C. Chen, W.C. Hsu, and M.K.Lu. 2002. Antrodia camphorata polysaccharides exhibit anti-hepatitis B virus effects. FEMS Microbiology Letters 209: 63-67.(SCI)

14.Huang, R.L., Y.L. Huang, J.C. Ou, F.L. Hsu, C.M. Chang, and C.C.Chen. 2003. Screening of 25 Compounds Isolated from Phyllanthus Species for Anti-Human Hepatitis B Virus In Vitro. Phytotherapy Research 17:449-453. (SCI)

15.M.D. Wu, R.L. Huang, L.M. Yang Kuo, C.C. Hung, C.W. Ong, and Y.H.Kuo. 2003. The Anti-HBsAg and Anti-HBeAg C18 Dibenzocyclooctadiene Lignans from Kadsura matsudai and Schizandra arisanensis, Chem. Pharm. Bull. 51(11) :1233-1236. (SCI)

16.沈建昌,郭育綺,黃瑞齡, 林麗純,董明兆,張東柱,周正仁2003牛樟芝成份之研究中醫藥雜誌 14(4): 247-258.

17.Chen, C.C. Y.L. Huang, Y.J. Shiao, R.L. Huang, T.T. Fu, and C.C.Shen. 2003. Synthesis of Antioxidative Moscatilin and its Bibenzyl Derivatives. The Chinese Pharmaceutical Journal 55: 381-390.

18.Huang, R.L., Quillan Huang, C.F. Chen, T.T. Chang, and C.J. Chou.2003. Anti-Viral Effects of Active Compounds from Antrodia camphorate on Wild-Type and Lamivudine-Resistant Mutant HBV. The Chinese Pharmaceutical Journal 55: 371-379.

19.Teng, W.Y., Y.L. Huang, R.L. Huang, R.S. Chung, and C.C. Chen.2004. Biotransformation of Imperatorin by Aspergilus flavus. Journal of Natural Products 67, 1014-1017. (SCI)

20.Don, M.J., Y.J. Huang, R.L. Huang, and Y.L. Lin. 2004. New Phenolic Principles from Hypericum sampsonii. Chem. Pharm. Bull. 52(7):866-869. (SCI)

21.Kuo, Y.H., M.D. Wu, C.C. Hung, R.L. Huang, L.M.Y. Kuo, Y.C. Shen,and C.W. Ong. 2005. Syntheses of C18 dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents. Bioorganic & Medicinal Chemistry 131555 - 1561. (SCI)

22.Huang, H.L., C.C. Chen, C.Y. Yeh, and R.L. Huang*. 2005. Reactive oxygen species mediation of Baizhu-induced apoptosis in human leukemia cells. Journal of Ethnopharmacology. 97(1):21 - 29. (SCI)

23.Teng, W.Y., Y.L. Huang, C,C, Shen, R.L. Huang, R.S. Chung, and C.C.Chen. 2005. Cytotoxic acridone alkaloids from the stem bark of Citrus maxima. Journal of the Chinese Chemical Society 52:1253-1255

24. Lee M-S, Lien Y-Y, Feng S-H, Huang R-L, Tsai M-C, Chang W-T, Chen H-J, 2009. Production of chicken anemia virus (CAV) VP1 and VP2 protein expressed by recombinant Escherichia coli.  Process Biochemistry 44390-395 (SCI)

25. 盧泯任、李孟修、陳錫金、黃瑞齡. 2009 大溪地等鞭金藻抗B型肝炎病毒野生型及lamivudine抗藥性突變株作用之探討.美和技術學院學報28(1)39-53

26. Damodar Janmanchi, Ya Ping Tseng, Kuei-Chen Wang, Ray Ling Huang, Chih Hsiu Lin,Sheau Farn Yeh. 2010. Synthesis and the biological evaluation of arylnaphthalene lignans as anti-hepatitis B virus agents.  Bioorganic & Medicinal Chemistry 181213-1226 (SCI)

27.盧泯任、李孟修、陳錫金、吳裕仁、黃瑞齡. 2011五爪金英Td-F2萃取物誘導人類肝癌細胞Hep3B細胞週期阻滯及細胞凋亡作用.美和學報31(1)15-34

 

(B)研討會論文 CONFERENCE PAPER

1.黃瑞齡、陳威全、王正隆、劉至一、溫雅蘭. GK001萃取物抗B型肝炎病毒野生型及lamivudine抗藥性突變株作用之探討. 2006南台灣健康產業研討會pp.526~532.

2.黃瑞齡、鄭德志、劉增容、謝桂鈺、戴瑄. 五種藥用蕈類萃取物抗B型肝炎病毒野生型及lamivudine抗藥性突變株作用之探討. 2006南台灣健康產業研討會 pp.540~545.

3.黃瑞齡、陳春香、施慧娟、郭家綺、王正隆.中草藥抗流感病毒H1N1測定平台之建立.2007南台灣健康產業研討會pp.214~218.

4.盧泯任、陳文泓、陳建志、黃瑞齡. 紫蘇醇抗B型肝炎病毒野生型及lamivudine抗藥性突變株作用及機制之探討. 2008高雄醫學大學天然藥物研討會

5.黃瑞齡、戴瑄、謝桂鈺、施慧娟、鄭德志.Perillyl Alcohol抑制人類C型肝炎病毒作用之研究 .2008南台灣健康產業研討會pp.325~334.

6.黃瑞齡、施慧娟、溫雅蘭、郭家綺、陳春香.歐前胡素抗B型肝炎病毒作用之探討.2009南台灣健康照護與健康產業學術研討會pp.64~73.

7.黃瑞齡、林子軒、沈賈堯、陳春香、黃義仁.琥珀中古生物DNA之探討. 2010南台灣健康產業暨健康照護學術研討會pp.236~250.

8.黃瑞齡、謝桂鈺、沈賈堯、施慧娟、鄭德志.穿心蓮抗腫瘤作用之探討 2010南台灣健康產業暨健康照護學術研討會pp.251~263.

9.Ray-Ling Huang1,*, Huei-Fang Lin2, Jyh-Fei Liao2, Chien-Chang Shen3, and Chien-Chih Chen. Dicentrine derivative induced G2/M arrest and apoptosis in human cancer cells as a potent topoisomerase II inhibitor  2010 Green Biotechnology International Symposium-International cooperation for promoting the development of green biotech industry

10. Min-Ren Lu1, Wen-Fei Chiou2 , Yu-jen Wu3 and Ray-Ling Huang4*. Selective fraction of Tithonia diversifolia induced cell cycle arrest and apoptosis on Hep-G2 human hepatoma cells. 2010 Green Biotechnology International Symposium-International cooperation for promoting the development of green biotech industry

11.Ray-Ling Huang1 *, Zen-Hong Shu1, Shu-Hui Lin2. Evaluation of Anti-HBV effects on One Power Supreme Ferment Extracts of Herbs. 2010 Green Biotechnology International Symposium-International cooperation for promoting the development of green biotech industry.

12.Hsi-Jien Chen1 *, Meng-Shiou Lee2, Ray-Ling Huang 3, Sin-Cheng Gong 4, Yu-Chi Chen 1. The investigation of dioxin bio-transformation bacteria in a real site of Taiwan. 2010 Green Biotechnology International Symposium-International cooperation for promoting the development of green biotech industry.

13.黃瑞齡、蘇瑞欣、郭家綺、沈賈堯. 艾草萃取物之抗B型肝炎病毒活性試驗. 2011南台灣健康照護暨健康產業國際學術研討會pp.82~98.

14.黃瑞齡、施慧娟、陳春香、潘孝萱. 艾草萃取物之抗B型肝炎病毒活性試驗. 2011南台灣健康照護暨健康產業國際學術研討會pp.180~191.

15.吳欣君、陳文泓、黃瑞齡. 五爪金英誘導人類惡性腦瘤U87細胞凋亡作用之研究. 2012南台灣健康照護暨健康產業學術研討會pp.64~65.

16.林子文、蘇惠珍、林昀生、黃瑞齡. 白朮內酯I誘發人類血癌細胞凋亡作用及機制之探討. 2012南台灣健康照護暨健康產業學術研討會pp.145~146.

17.黃博玲、翁汶燦、戴明泓、黃瑞齡. A Study on the Angiogenesis Function of Melanotan II in the Endothelial cells. 2012南台灣健康照護暨健康產業學術研討會p.144.